• We identified an acquired ceritinib resistance mechanism cau

  2018-10-30

  

  We identified an acquired ceritinib-resistance mechanism caused by P-gp overexpression in an ALK-rearranged NSCLC patient who was receiving ceritinib therapy. We also demonstrated that ceritinib is a P-gp substrate and that P-gp inhibition reversed ceritinib and crizotinib resistance. While our manu

• br Subjects and Methods br Results br Discussion HnRNP A

  2018-10-30

  

  Subjects and Methods Results Discussion HnRNP A1 has been reported as an important autoantigen of the autoimmune response in rheumatic diseases in many articles. Autoantibodies to hnRNP complex have been detected in patients with RA, SLE and mixed connective tissue disease in succession (so

• The link to dietary protein quality is

  2018-10-30

  

  The link to dietary protein quality is of particular interest from a public health lens; as the authors note, “dietary intake of essential order Paclitaxel may be insufficient in children with stunting”. Previous research supports this hypothesis: An analysis of dietary and anthropometric data colle

• Although low baseline virus load

  2018-10-29

  

  Although low baseline virus load is considered one of the predictive factors for SVR12, many other host, virus and drug related factors are also important and can sometimes affect the virus response to treatment regardless of baseline virus load. The significant existence of Resistance Associated Su

• The Lothian Birth cohorts of and are studies that

  2018-10-29

  

  The Lothian Birth cohorts of 1921 and 1936 are studies that were initiated in 1999 and 2004 respectively, originally aimed at uncovering the genetic determinants of cognitive aging. These are follow up studies to the Scottish mental survey that tested the intelligence of almost all children aged 11

• The linkage map underpinning the B

  2018-10-29

  

  The linkage map underpinning the B. napus pseudomolecule arrangement was based on a mapping population of only 37 genotyped lines. This limited the resolution of the resource as the 21, 323 mapped markers defined only 527 recombination bins [7]. By increasing the size of the genotyped population to

• Funding from the German Federal Ministry of Education

  2018-10-29

  

  Funding from the German Federal Ministry of Education and Research (BMBF) supported parts of this study (Funding code FKZ 16I1619). The Leibniz Center for Agricultural Landscape Research (ZALF) is institutionally funded by the Federal Ministry of Food and Agriculture (BMEL) and the Ministry for Scie

• br Experimental design materials and methods The

  2018-10-29

  

  Experimental design, materials and methods The original map was obtained as a TIFF image from [1] and was imported to GlobalMapper v11.01 (Global Mapper Software LLC). The image was then combined with a basemap of South America and the limits of each province and subprovince were set and adjusted

• Earlier mentioned protocols were followed

  2018-10-29

  

  Earlier mentioned protocols [1,2] were followed right from the extraction up to qualitative and quantitative analysis of diatoms. Diatoms were identified on the basis descriptions available in the literature [3]. Distribution patterns of diatoms have been displayed in Table 4. Photomicrographs of so

• At the cellular level DCDC is involved in

  2018-10-29

  

  At the cellular level DCDC2 is involved in processes such as cellular defense response, dendrite morphogenesis, intracellular signal transduction, regulation of smoothened signaling pathway, regulation of Wnt signaling pathway, and regulation of cilium assembly. At the systems level, DCDC2 is correl

• To date only a few studies

  2018-10-29

  

  To date, only a few studies have evaluated SES-related disparities in neural mechanisms of selective attention in children. All these studies revealed neurophysiological differences in children from lower compared to higher SES backgrounds (D’Angiulli et al., 2008; Kishiyama et al., 2009; Stevens et

• Scipioni et al and Chiapasco et al recommended

  2018-10-29

  

  Scipioni et al. [21] and Chiapasco et al. [34] recommended that the periosteum should not be stripped off the labial plate in order not to affect the blood supply and to allow rapid revascularization of the expanded plate of bone. The periosteum has another function in treating the mal-fractures tha

• br Methods br Results br Discussion Is it possible to

  2018-10-29

  

  Methods Results Discussion Is it possible to predict the social structure of space using space syntax techniques? The answer appears to be positive. The first proposal, with the straight linear pathway, did not show significant changes in the visual integration analysis through Depthmap. Th

• Fig also shows that of the respondents will link

  2018-10-29

  

  Fig. 12 also shows that 82% of the respondents will link an neurokinin 1 receptor analysis tool to a BIM model to analyze a building׳s solar, ventilation, and air flow requirements, which is closely followed by 72.3% of respondents who will link an energy analysis tool to a BIM model to optimize th

• In molecular genetics most synovial sarcomas demonstrate a

  2018-10-29

  

  In molecular genetics, most synovial sarcomas (90%) demonstrate a specific translocation between chromosome X and chromosome 18 (p11.2; q11.2). This includes the SYT gene on chromosome 18 and one of several homologous genes (SSX1, SSX2, and SSX4) on the X chromosome. This leads to the expression of

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