• br The role of LOX plays in

  2024-12-20

  

  The role of 12/15-LOX plays in autophagy Autophagy is a process by which cellular material is delivered to lysosomal to degrade the damaged organelles and proteins to facilitate nutrient recycling (Towers and Thorburn, 2016). There has been characterized three types of autophagy-macroautophagy, m

• Asparagine synthetase ASNS is a glutamine amidotransferase

  2024-12-20

  

  Asparagine synthetase (ASNS) is a glutamine amidotransferase that catalyzes ATP-dependent synthesis of asparagine and glutamate from aspartate and glutamine. Upregulation of ASNS expression renders leukemia cells resistant to l-asparaginase treatment, and ASNS is essential for cell survival in the a

• AR is an enzyme involved in conversion of glucose into

  2024-12-20

  

  AR is an enzyme involved in conversion of glucose into sorbitol using NADPH as a cofactor [46]. This AR polyol pathway generates sorbitol accumulation and NADPH depletion. NADPH participates in detoxification via glutathione (GSH) reductase pathway [47]. Therefore, reduction of NADPH attenuates remo

• br Materials and methods br Results

  2024-12-20

  

  Materials and methods Results Discussion Wound healing of the human cornea is a complex process that requires cell migration and proliferation. Corneal wound healing is characterized by major changes in the composition of the ECM such as a massive transitory secretion of fibronectin combine

• br Conclusion br Acknowledgement This work was supported by

  2024-12-20

  

  Conclusion Acknowledgement This work was supported by JSPS KAKENHI (Grant Number 15K18770). Introduction Neural crest dabigatran etexilate are multipotent progenitors in the vertebrate embryo that give rise to a vast array of different cell types including pigment cells, craniofacial skel

• The surprising finding of our study is that human M

  2024-12-19

  

  The surprising finding of our study is that human M1 macrophages stimulated by LPS express ALOX15B to high levels. So far 12/15-lipoxygenase activity was only reported for IL-4 stimulated anti-phlogistic M2 macrophages [9] but not for the classically activated M1 macrophages. Our data suggest that s

• br The role of apelin in cancer Studies on cancers

  2024-12-19

  

  The role of apelin in cancer Studies on cancers are intensively conducted worldwide. It is thought that this large family of diseases is among the most studied. The researchers test newly-discovered substances hoping to find remedies and diagnostic indices for this illness. One of such substances

• HMGN proteins are subject to extensive post

  2024-12-19

  

  HMGN proteins are subject to extensive post-translational modifications which influence both their mode of binding to Cryptochlorogenic acid and their functional activity. Like the other HMG protein families, HMGNs are substrates for many of the same enzymes that modify histone proteins (review in

• br Introduction Androgens have been

  2024-12-19

  

  Introduction Androgens have been shown to regulate several neural functions ranging from reproduction to mood and cognitive abilities. This property starts as early as the perinatal period, which is characterized by prenatal and postnatal surges of gonadal testosterone, and continues through pube

• Interestingly metabolic dysfunction is also

  2024-12-19

  

  Interestingly, metabolic dysfunction is also observed in amyotrophic lateral sclerosis (ALS). Patients and mouse models of familial ALS exhibit higher levels of resting AZD-9291 expenditure and lower fat-free mass, indicating a hypermetabolic phenotype. Lim et al. (2012) found that reducing AMPK act

• br Materials and methods br Results br

  2024-12-18

  

  Materials and methods Results Discussion Intracellular metabolic pathways of sugar, such as glycolysis and TCA cycle, provide material and energy for the synthesis of other substances, including amino acids. Thus, the content of sugars and their metabolic pathways are important for amino ta

• br Aldehyde sensors to monitor substrate levels

  2024-12-18

  

  Aldehyde sensors to monitor substrate levels Previous efforts to ameliorate metabolic diseases frequently relied on biochemical methods which could measure the levels of toxic substrates in nor-NOHA acetate or bodily fluids (blood and serum or plasma, urine, cerebrospinal fluid). Therapeutic eff

• The fact that Yoda can activate Piezo in the absence

  2024-12-18

  

  The fact that Yoda1 can activate Piezo1 in the absence of other cellular components other than a cell membrane [2], suggests that it may directly interact with and activate Piezo1. However, this does not preclude Yoda1 from interacting and activating non-Piezo channels, particularly in endothelial c

• Nrf br AhR br Nrf and

  2024-12-18

  

  Nrf2 AhR Nrf2 and AhR: friends or foes for energetic metabolism? Perspectives in carcinogenesis upon xenobiotic exposure Acknowledgements Introduction Integration of endogenous and exogenous signals via appropriate receptors is at the core of biological differentiation and adaptive r

• The most potent compounds within the current series of compo

  2024-12-18

  

  The most potent compounds within the current series of compounds were therefore , , , , and , with PD 0332991 possessing the best selectivity towards the lyase reaction in comparison to the hydroxylase reaction, indeed, this compound was found to possess an IC value of 1210nM against the 17α-OHas

16157 records 34/1078 page Previous Next First page 上5页 3132333435 下5页 Last page