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  • In the present study synthesis of Bi MoO

    2019-09-09

    In the present study, synthesis of Bi2MoO6 nanoplates via DNA-templated hydrothermal method has been undertaken. The synthesis was done through the hydrothermal method by means of the reaction of bismuth nitrate pentahydrate (Bi(NO3)3·5H2O) with sodium molybdate dihydrate (Na2MoO4·2H2O) precursor in the presence of DNA template and it is capable of completely generating the Bi2MoO6 nanoplates. The prepared Bi2MoO6 nanoplates have been subsequently employed for the fabrication of electrochemical supercapacitor electrodes. The synthesis method is cost-effective, simple, less time consuming and hence expected to provide reproducible results. Till date, such an approach in the direction of the use of Bi2MoO6 nanoplates (prepared via DNA templated hydrothermal method) as a supercapacitor electrode material has not been reported thus far.
    Experimental
    Results and discussion
    Conclusion In this endeavour, a simple and cost-effective DNA-templated hydrothermal method was employed for the synthesis of high-performance electrochemical supercapacitive Bi2MoO6 electrode material. The structural properties of the prepared Bi2MoO6 material were evaluated and confirmed using XRD, FTIR and confocal Raman spectroscopic analyses. The morphological analysis shows that the prepared Bi2MoO6 material exhibits thin nanoplate structure and the highest specific capacitance of 698 Fg−1 at a scan rate of 5 mV s−1 in comparison with other specimens. Interestingly, cycling stability results have revealed the probability of 86% retention of the initial specific capacitance after 3000 cycles in the case of BM-3 telomerase inhibitor specimen. Based on the above results, the newly prepared Bi2MoO6 (BM-3) nanoplates are considered to be a potential candidate for supercapacitor devices.
    Acknowledgement The financial support received in the form of DST-PURSE PHASE-II programme from Department of Science and Technology (DST), Government of India, New Delhi is gratefully acknowledged. One of the authors (J. Yesuraj) would like to thank Mr. K. Rajesh for his fruitful discussions during this endeavor.
    Introduction DNA molecule remains the most desirable target in anticancer studies [1]. Thus, the design and characterization of DNA binding and cleaving agents have been an active area of research for decades [2]. Small telomerase inhibitor can bind to DNA through covalent and non-covalent interactions [3]. The latter includes three different binding modes: electrostatic interactions with the phosphate backbone, intercalation between DNA base pairs, and groove binding [4]. Among these interactions, intercalating binding proved to be one of the most efficient modes for the development of DNA targeting compounds [5]. Intercalators are small organic molecules with planar aromatic moieties that insert between DNA base pairs resulting in the modification of the native DNA structure [6]. The accommodation of an intercalator induces a crucial perturbation in the DNA molecule: it unwinds the helical twist and causes DNA lengthening [7]. This deformation might result in the vital errors in such important biological functions as DNA replication and transcription [8]. Thus, intercalators represent a promising class of compounds that are used as lead structures for anticancer drugs design [9]. In addition to a distortion of a DNA molecule caused by the intercalation, either thermal or photoinduced damage can be caused by DNA cleaving agents. Photoswitchable DNA cleavers were most accurately described by Armitage as ‘compounds whose excited states can initiate a series of chemical reactions which ultimately lead to nucleic acid cleavage’ [10]. DNA photocleavers typically absorb at a wavelength longer than 300nm [11]–the region where nucleic acids and the majority of proteins are transparent, which helps to selectively excite a photocleavage agent. Photoswitchable DNA damaging agents have a number of advantages over the thermally activated compounds [12]. Among these advantages is the prior binding of a photocleaver to DNA molecule before the irradiation and ‘light-clicking’ reaction management: light allows to control the reaction in both spatial and temporal ways [13]. These unique properties have triggered the search for efficient DNA photocleaving agents. Although photoswitchable ligand complexes of transition metals have been thoroughly investigated and their design still remains an extensive research area [14], smaller number of studies cover ‘light-clicking’ small organic molecules capable of intercalating in DNA structure. Examples of photoactivated organic compounds include, for instance, enediynes [15], naphthalimide [16] and pyrene derivatives [17].