melk inhibitor The limitations of our study include a relati

The limitations of our study include a relatively small sample size and that serum samplings for inflammatory complement components and other inflammatory mediators were performed at one time point (before subjects went to bed). The serum levels of inflammatory molecules, e.g., IL-6, C-3, and C-4, exhibit distinct circadian patterns in healthy individuals [14,36]. The blood sampling was done during a close range of time to avoid the effect of the circadian variability on the serum levels of the measured inflammatory molecules. Therefore, observation of the serum levels of inflammatory molecules at multiple time points may provide pertinent information about the circadian rhythm-dependent dynamics of their relation to sleep. However, the use of catheters for repeated blood sampling increases IL-6 locally [37]. Therefore, future studies should account for this fact to provide a comprehensive understanding of the association. Nevertheless, this is the first study to report that the inflammatory mediators across three melk inhibitor of immune-regulatory molecules of cytokines, cell adhesion molecules, and complement components are similar in their associational dynamics with sleep. This study is a preliminary study to investigate the relationship between objective measures of sleep and inflammatory complement components. The normal level of oxygen desaturation index (4.33±2.93) and mean SpO2 (95.90±0.83) indicated absence of apnea in the participants [38].
Conclusion
Conflicts of interest of each author/contributor
Acknowledgment We thank all the study volunteers who took time from their busy schedules to participate in the study. The Indian Council of Medical Research (Grants no. 3/1/JRF-2007/MPD), the University Grants Commission (Grants no. 37-222/2009 (SR-)) and the Strategic Technologies Program of the National Plan for Sciences and Technology and Innovation in the Kingdom of Saudi Arabia funded the research. None of the study sponsors played a role in the study design, the collection, analysis or interpretation of data, writing the manuscript, or the decision to submit the manuscript.