br A hallmark of the past decade
A hallmark of the past decade has been the remarkable progress made in reducing maternal and child mortality, an achievement credited in some measure to the Millennium Development Goals. The reduction in child deaths from an estimated 12·7 million under-5 deaths in 1990 to fewer than 6 million deaths by 2015 is a remarkable achievement in global health. The fact that this reduction is less than uniform and varies widely between countries and in populations within countries has also been well recognised. The usual measures of such differentials have included both direct measures of mortality and coverage of key lifesaving interventions. In its last report, the independent expert review group for maternal and child health reported that the well-known mortality gradient by socioeconomic status was not evident for newborn mortality. The study by Marshall Burke and colleagues evaluated geospatial trends in under-5 mortality from 82 Demographic and Health Surveys in 28 countries in sub-Saharan Africa. The investigators used a 10 km × 10 km matrix to map under-5 mortality and assessed the association between changes in mortality and clustering with contextual and relevant data from Demographic and Health Surveys and other data sources. Their analysis shows that most (75%) of the variation in under-5 mortality could be explained by sub-national factors with the SGX-523 factors being climate change, malaria burden, and conflict. Several limitations should be considered when assessing the work, such as limited availability of local health system information at the level of granularity needed for geospatial analysis, limited information on population migration patterns, and the timings of the surveys. Another limitation is the lack of information on disaggregated mortality analysis by age groups (such as for neonatal mortality versus post-neonatal mortality) or indeed analysis by cause of deaths. These limitations notwithstanding, the general findings that changes in under-5 mortality and clustering frequently transcended boundaries and were more responsive to local factors than to national factors are important and borne out by other evidence. Murray and colleagues first pointed out the enormous disparities in epidemiological patterns of adult mortality in the USA and coined the term “eight Americas” in 2006, and subnational geographic disparities in relation to childhood mortality and stunting have been studied in several low and middle-income countries (LMICs). What are the implications of such analyses for the future? Geospatial depictions of differentials in mortality, as well as access to services and coverage of interventions, represent an extremely powerful approach to the assessment of inequities. Although Burke and colleagues did not relate mortality trends to subnational or regional administrative units, these are critically important in understanding more proximal determinants and policy responses to disparities. In an analysis of life expectancy patterns by counties, investigators from the Institute of Health Metrics and Evaluation estimated that, against a time-series of life expectancy in the ten nations with the lowest mortality, counties in the USA ranged from being 15 calendar years ahead for men and 16 calendar years ahead for women to more than 50 calendar years behind for both sexes. In other more complex analysis sexual reproduction used regular reporting system information from 2851 counties of 31 provinces in mainland China, Wang and colleagues used small area mortality estimation models, spatiotemporal smoothing, and Gaussian process regression to synthesise data and obtain county-level mortality estimates. Linking of geospatial data to administrative units can be an extremely powerful advocacy and planning tool, especially in LMICs. A major limitation, however, is one of data availability at the level of the smallest administrative units and the power of the surveys at that level of specificity. Although Bayesian methods are often used in such analyses at these smallest of sampling units, such assessments are fraught with errors according to measures used and neighbourhood effects, and such analytical methods are beyond the capacity of most health system programmes for monitoring and evaluation. However, these analyses and their depiction are hugely effective for conveying complex messages and targeting of efforts to reduce disparities.