br Results and discussion br Conclusion In

Results and discussion
Conclusion In conclusion, twenty-one 4-monocyclic aryl-5-carbamoyl-3-isoxazolols have been synthesized and evaluated for their antagonistic activities against housefly and common cutworm GABARs expressed in Xenopus oocytes. The TEVC results indicated that PF 1022A several compounds exhibited excellent antagonism in both insect GABARs, with IC50 values at the micromolar level ranging from 0.9 to 12.9 μM. All synthesized analogues showed moderate larvicidal activities against common cutworms at 100 μg/g. The findings obtained in saprophytes study provide important information for designing potent GABAR CAs.
Experimental
Acknowledgments This work was supported by the National Natural Science Foundation of China (No. 21807082), the Hubei Provincial Natural Science Foundation of China (No. 2017CFB121), and the Hubei Provincial Department of Education of China (No. Q20171503).