• Cy5.5 carboxylic acid (non-sulfonated) A previous study repo

  2023-01-02

  

  A previous study reported that the serotonergic mechanism was involved in the psychological stress-induced alteration in synaptic plasticity in the rat hippocampal CA1 field (Matsumoto et al., 2004). Sumitaka Inoue et al. (Inoue et al., 2014) reported that pretreatment with a 5-HT1A receptor partial

• The following are the supplementary data related

  2022-12-29

  

  The following are the supplementary data related to this article. Competing interest Ethics approval and consent to participate Authors' contributions Acknowledgements The authors thank Dr. D. R. Kaplan for kind advice and materials derived from NB primary cell lines, Dr. F. D. Miller f

• Although the earlier studies focused on the antioxidant

  2022-12-27

  

  Although the earlier studies focused on the antioxidant capacity of tocopherols, ascorbic 22 9 mg and carotenoids, then it was noticed that phenolic compounds were more powerful than others (Rice-Evans, Miller, & Paganga, 1996). Phenolic compounds, the most numerous and ubiquitous groups of plant s

• br Discussion Hepatic dysfunction in

  2022-12-23

  

  Discussion Hepatic dysfunction in the metabolic syndrome is a driver of negative patient outcomes that requires more therapeutic options. The complexity of liver alterations in this disease – elevated de novo synthesis of fatty acids and cholesterol, reduced clearance of circulating atherogenic L

• br AHR mediates TCDD toxicity and

  2022-12-21

  

  AHR mediates TCDD toxicity and wasting syndrome TCDD causes numerous toxicities in laboratory animals, including teratogenesis, hepatic steatosis, thymic atrophy, immune dysfunction and a lethal wasting syndrome [17]. The dose-dependent sensitivity to TCDD-induced toxicities varies widely among l

• br Experimental procedure br Introduction Migraine is a debi

  2022-12-21

  

  Experimental procedure Introduction Migraine is a debilitating neurovascular disorder characterized by recurring unilateral pulsating headaches of moderate to severe intensity, associated with nausea, photophobia and/or phonophobia, lasting from 4 to 72 h (Headache Classification Committee of

• For comprehensive understanding of actin myosin XI as

  2022-12-21

  

  For comprehensive understanding of actin-myosin XI as a control network, it will be necessary to determine the functions of all the myosin XI and Sulfo-NHS-SS-Biotin isoforms. However, it is difficult to reveal the function of individual myosin XI isoforms because most myosin XI single knockouts ex

• Qualitative inspection of the single channel traces presente

  2022-12-21

  

  Qualitative inspection of the single-channel traces presented in both Figures 3 and 4 shows that within bursts of activity, βAnc-containing AChRs display a marked reduction in open probability. To quantify these differences in single-channel behavior, we performed dwell-time analysis under high-reso

• Hypoxia induced replication arrest has been demonstrated

  2022-12-17

  

  Hypoxia-induced replication arrest has been demonstrated in a variety of organisms in addition to mammals; including Zebrafish , , and (brine shrimp) which have been shown to survive for 4 years and longer in anoxic conditions . Despite this breadth of study, little is known about the mechanism of

• GABAB receptor is associated with brain and behavioral disea

  2022-12-17

  

  GABAB receptor is associated with acridine orange and behavioral diseases, including epilepsy, spasticity, anxiety and neuropathic pain (Bettler et al., 2004, Bowery et al., 2002, Froestl, 2010). Baclofen, a clinical drug and selective GABAB receptor agonist, is used to treat muscle spasticity in p

• Interestingly ZIP expression was decreased

  2022-12-16

  

  Interestingly, ZIP9 expression was decreased in dog testes after they were implanted with gonadotropin releasing hormone (GnRH) which the authors proposed was due to androgen ablation (Bulldan et al., 2016a). The expression of other members of the ZIP (SLC39A) family has also been shown to be regula

• Previous studies have thus demonstrated that AR activation g

  2022-12-16

  

  Previous studies have thus demonstrated that AR activation generally correlates with the promotion of urothelial carcinogenesis and cancer growth. In this article, we review available data suggesting their modulation through the AR pathway as well as correlations of AR signals with sensitivity to co

• Based on their different sources the APN inhibitors APNIs ca

  2022-12-16

  

  Based on their different sources, the APN inhibitors (APNIs) can be divided into the natural products and synthetic compounds. Bestatin (1, Fig. 1), isolated from the Streptomyces oliuoreticuli by Umezawa et al., is the first reported and only marketed natural dipeptidomimetic inhibitor of APN. Afte

• Synthesis of the pterin carboxamides was achieved

  2022-12-15

  

  Synthesis of the pterin-7-carboxamides was achieved, as shown in , based on a previously reported method that utilizes DBU as a key additive to dissolve pterin in organic solvents and accelerate the reaction., With this method, the pterin-amino glutamate receptor antagonist conjugates (–) were rea

• EIPA We now present a series of findings obtained in

  2022-12-15

  

  We now present a series of findings obtained in heterologous expression systems, brain slices, and living animals that suggest that any interaction between mGlu7 and α1-adrenergic receptors exists, is specific, and is physiologically and behaviourally relevant. Materials and methods Norepinephri

13811 records 211/921 page Previous Next First page 上5页 211212213214215 下5页 Last page