Archives
-
The lack of effective strategies aiming to directly increase
2021-04-20
The lack of effective strategies, aiming to directly increase the neuronal survival, is reflected by the fact that the only available therapeutic interventions are indirect. They consist of acute therapeutic interventions involving chemical and/or surgical removal of the thrombotic clot (Taqi et al.
-
In essential hypertensive patients it is known that the
2021-04-20
In essential hypertensive patients, it is known that the CB is enlarged (Habeck, 1986). In addition to morphological changes in the CB, hyperventilation was reported in essential hypertensive patients at resting conditions (Trzebski et al., 1982). Furthermore, CB is innervated by postganglionic symp
-
br Application of D receptor
2021-04-20
Application of D1-receptor PET in psychiatric disorders Discussion Compared to other markers of the DA system, only a limited number of studies have investigated D1-R in psychiatric disorders. In schizophrenia, which is the most studied condition with a total of 83 identified unique patients,
-
The current study provides evidence for a
2021-04-20
The current study provides evidence for a previously unknown role for DHODH as a growth/survival factor in KRAS mutant tumors. While many aspects of the link between DHODH inhibition and survival of KRAS mutant cells remain to be established, de novo pyrimidine biosynthesis appears to be a crucial p
-
Some limitations to our study should
2021-04-20
Some limitations to our study should be noted. First, the sample size of our study was limited. As DDR2 mutations are rare in lung SCC, it is possible that the power of our study was insufficient to detect potential associated factors. Second, a significant proportion of the 271 sequenced patients h
-
The CysLT receptor antagonist BayCysLT RA significantly
2021-04-20
The CysLT2 receptor antagonist BayCysLT2RA significantly suppressed multiple antigen challenge-induced infiltration of eosinophils and mononuclear Dihydroartemisinin into the lung, indicating that CysLT2 receptor activation is involved in leukocyte migration. In contrast to the present finding, Bar
-
Although it is believed that CYP induction
2021-04-20
Although it is believed that CYP induction is regulated in humans in principle in the same fashion as in animals, some species differences in CYP3A enzymes induction were observed. Rifampicin is known to be a potent inducer of CYP3A4 in human hepatocytes, whereas pregnenolone-16α-carbonitrile (PCN)
-
In vivo study showed that
2021-04-20
In vivo study showed that the CYP3A activity was increased, when morroniside (10, 30 and 90 mg/kg, i.g.) was daily for seven consecutive days. Further, RT-PCR analysis showed that the induction of mRNA PD 169316 by morroniside (10, 30 and 90 mg/kg, i.g.) was 1.13-, 1.43- and 1.79-fold higher, respec
-
Based on the ability of CRF to modulate nociception
2021-04-19
Based on the ability of CRF to modulate nociception, we hypothesized that stress leads to hyperalgesia by the activation of CRF1 and/or CRF2 receptors in the spinal cord. We tested this hypothesis using an acute forced swim as a widely used and easily reproducible stressor and grip force as a measur
-
Secondary and primary studies have considered the decision t
2021-04-19
Secondary and primary studies have considered the decision to select the provider and to select components after the component origin is chosen. Examples of secondary and primary studies outside our scope, but still related to decision-making are listed in Tables 1 and 2. The secondary and primary s
-
br Atypical collagen glycosylation The
2021-04-19
Atypical collagen glycosylation The disaccharide Glc(α1-2)Gal(β1-O) decorating collagens is strongly conserved across the animal kingdom, yet for every rule, nature provides exceptions. The deep-sea worm Riftia pachyptila of the phylum Annelida represents an intriguing exception. R. pachyptila is
-
br Introduction Phosphorus P is
2021-04-19
Introduction Phosphorus (P) is an important nutrient for plant growth; however, in many regions of the world soils are low in plant-available P (Holford, 1997). Therefore, P fertilisers play an important role in agriculture. Most P fertilisers in current use are derived from phosphate rock; howev
-
br Materials and methods br Results and discussion br Conclu
2021-04-19
Materials and methods Results and discussion Conclusions The current research work deals with preparation of CES from RHA and comparative study of Ni (II) ion adsorption on CES and RHA. It was observed that carbon embedded silica shows more porous structure and more surface area as compared
-
br Iterative design approach overview An iterative design st
2021-04-19
Iterative design approach overview An iterative design strategy is used to identify a peptidase-resistant reporter that acts as an efficient substrate for kinases in cell lysates as well as intact cells (Fig. 1). In this process, small-scale, rationally designed libraries are used to screen pepti
-
It is particularly notable that CYP D
2021-04-19
It is particularly notable that CYP2D6 appears to be the most stable of the major CYP450 MTEP hydrochloride in its expression over time in vitro and appears to be least affected by culture conditions and sample to sample variability (i.e., CYP2D6 expression is remarkably consistent over time and be