Archives
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br Acknowledgements br Introduction Acute lung
2020-07-31
Acknowledgements Introduction Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS), a more severe form of ALI, are devastating clinical syndromes characterised by alveolar-capillary membrane hyper-permeability, oedema, infiltration of neutrophils into interstitial spaces, neu
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br Conclusions The s s of Pb and
2020-07-31
Conclusions The s/s of Pb and Cu contaminated slurry using cement and rice husk ash (RHA) was investigated. This study investigated the potential of replacing 20%–40% of the cement used for the s/s of Cu and Pb with RHA. It was observed that an increase in the binder content from 100 kg/m3 – 300
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br Introduction Our understanding of
2020-07-31
Introduction Our understanding of how ligands interact with G protein coupled receptors is evolving, particularly the recognition that some have the ability to preferentially activate a subset of intracellular signalling cascades – so called pathway biased ligands [1]. Additionally, it is now acc
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Most of the methods developed for enzyme extraction
2020-07-30
Most of the methods developed for enzyme extraction have focused on the development of aqueous biphasic systems for purification using neutral salts, polymers or ligands (Nadar et al., 2017), similar to those previously described with pineapple and papaya. However, in these cases, only the use of fr
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We not only found that the
2020-07-30
We not only found that the ISR leads to attenuation of conventional cap-dependent translation with no change in RAN translation of the G4C2 expanded repeat, but also that GA translation from the expanded repeat (but not from 5 G4C2 repeats, perhaps because the protein product does not aggregate) is
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br DGAT protein interactions Although
2020-07-30
DGAT-protein interactions Although DGAT1 and DGAT2 are membrane proteins of the ER, the ER contains within its extensive three-dimensional network different, unique structural and functional protein domains that arise from the non-uniformity imposed on it by the intracellular structures it inter
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Based on these results we set out to identify
2020-07-30
Based on these results, we set out to identify and molecularly characterize proteins downstream of DDR1. We performed a modified two-hybrid screen, where the bait and the target library were expressed in bacteria [16]. Fusing the intracellular domain of DDR1 to the bait protein and overexpression in
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br Summary Atg proteases play a crucial role in preparing
2020-07-30
Summary Atg4 proteases play a crucial role in preparing Atg8 for conjugation to lipid membranes and for the deconjugation of Atg8 from the autophagosomes (Till & Subramani, 2010). Of the four proteases, Atg4B is 1500-fold more catalytically efficient for LC3B activation than the other Atg4s, wher
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br Acknowledgements This work was supported by
2020-07-30
Acknowledgements This work was supported by the National Natural Science Foundation of China (40976065, 41576116). Introduction Arachidonic np e via cytochrome P-450 (CYP450) can elicit the formation of lipid mediators with vasoactive actions: the epoxyeicosatrienoic acids (EETs) mainly vaso
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Although the overall profile of was encouraging we pursued i
2020-07-30
Although the overall profile of was encouraging, we pursued its optimization based on SAR studies imported from a novel class of compounds in which the sulfonamide moiety of MK-7246 was replaced by an amide group. Potential liabilities related to the presence of a sulfonamides group (i.e., allergic
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Toxicological and safety studies performed to complete the
2020-07-30
Toxicological and safety studies performed to complete the profile of LAS191589 showed that so far, it is a safe compound. No issues have been detected in any of the studies performed in terms of cytotoxicity, cardiovascular safety, central nervous system safety and genotoxicity. No relevant adverse
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One of the genes whose expression was down regulated was
2020-07-30
One of the genes whose expression was down regulated was bgt-2 (NCU09175), encoding a β-1,3-endoglucanase. Deletion of this gene was shown to result in changes in Adenosine 5-monophosphate architecture suggesting that it is involved in remodeling of the cell wall (Martínez-Núñez and Riquelme, 2015)
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Herein we present a new
2020-07-30
Herein we present a new series of bisubstrate inhibitors incorporating either 4-(2-amino-1,3-thiazol-5-yl)benzoic Cy3 carboxylic acid (non-sulfonated) (ATB) moiety, a fragment that was previously introduced to inhibit CK2 by others39, 40, or 4-(2-amino-1,3-selenazol-5-yl)benzoic acid (ASB) moiety, t
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br Cellular and target recruitment In Figure
2020-07-29
Cellular and target recruitment In Figure 1, we present a simplified classification of the different layers of DUB regulation. The first layer we discuss is that of DUB recruitment factors. Guiding the almost 100 DUBs encoded in the human ACET to their relevant substrates and pathways is crucial
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Cystatins are potent inhibitors of
2020-07-29
Cystatins are potent inhibitors of cysteine proteases from the C1A family. These inhibitors primarily reduce the activities of cathepsin L-like proteases, although high concentration of barley cystatin hampers the degradation of storage proteins caused by cathepsin F-like protein (HvPap-1) (Cambra e