• Recently several groups reported that four orphan receptors

  2022-04-20

  

  Recently, several groups reported that four orphan receptors, GPR40, GPR41, GPR43, and GPR120, can be activated by free fatty acids. Short-chain fatty acids are specific agonists for GPR41 and GPR43 . Medium and long-chain fatty acids can activate GPR40 and GPR120 . Our previous report showed that

• br Discussion Our findings indicated that starting

  2022-04-20

  

  Discussion Our findings indicated that starting ART for asymptomatic HIV-infected pregnant women before their CD4 count falls below 500cells/mm3 is beneficial for CD4 normalization (CD4 recovery to 750cells/mm3 or more) in resource-limited settings. Women who started ART at lower baseline CD4 cou

• br Results and discussion br

  2022-04-20

  

  Results and discussion Conclusion In this study the first binding assays based on a nonlabelled reporter ligand addressing GlyT1 are described. Following the concept of MS Binding Assays recently introduced in our group, binding of the well-known GlyT1 inhibitor Org24598 employed as reporter l

• br Functional organization of postsynaptic glutamate

  2022-04-20

  

  Functional organization of postsynaptic glutamate receptors Downstream effects of glutamate receptor positioning Mechanisms underlying the subsynaptic positioning of glutamate receptors Conclusions and future prospects The molecular organization of synapses is undoubtedly a critical det

• br The hippocampus and spatial

  2022-04-20

  

  The hippocampus and spatial memory Numerous lines of evidence have implicated the rodent hippocampus in spatial forms of learning and memory (O’Keefe and Nadel, 1978). For example, hippocampal lesions produce robust and reliable deficits on spatial memory tasks such as the Morris watermaze in bot

• GKRP binds to the inactive

  2022-04-20

  

  GKRP binds to the inactive, super-open conformation of GCK, acting as a competitive inhibitor of glucose association with the enzyme (Fig. 3) [45]. Upon formation of the inhibitory complex with GKRP, GCK is sequestered into the hepatocyte nucleus [48]. The detailed mechanism by which GKRP mediates t

• It is increasingly argued that the immunosuppressive

  2022-04-20

  

  It is increasingly argued that the immunosuppressive effects of GCs are conferred indirectly by GR through the activation of genes encoding proteins that inhibit MK-8745 mg of proinflammatory genes 86, 87, 88. Genomic studies offer another mechanism compatible with the idea that GC-mediated repressi

• Recently unimolecular multi functional peptides

  2022-04-19

  

  Recently, unimolecular, multi-functional peptides that combine GLP-1RA activity with AEG 3482 and/or GIP activity have been suggested as new therapeutic agents for glycaemic and weight control. In rodents, dual GIP and GLP-1 receptor agonists achieve significantly better glucose control and weight

• br Regulation of plasma ghrelin concentration

  2022-04-19

  

  Regulation of plasma ghrelin concentration As described above, ghrelin is primarily produced in the stomach and secreted into the blood stream. Plasma ghrelin does not significantly differ between chronic heart failure (CHF) patients and controls, although plasma ghrelin level is significantly hi

• In conclusion starting from the weakly

  2022-04-19

  

  In conclusion, starting from the weakly potent GSM , exploration of various spacer groups between the triazole ring and the aromatic Ergosterol synthesis led to the discovery of a new series of potent gamma secretase modulators, with an improved drug-like profile—compared with the originally report

• br Materials and methods br Results br Discussion Induction

  2022-04-19

  

  Materials and methods Results Discussion Induction of neuronal cell death is the main neurotoxic mechanism of arsenite (Vahidnia et al., 2007). Previous studies have demonstrated that arsenite may trigger neuronal cell death via apoptosis, autophagy as well as necrosis (Yen et al., 2012; La

• Whether ferroptosis specific inhibitor could promotes spinal

  2022-04-19

  

  Whether ferroptosis specific inhibitor could promotes spinal cord repair is a question worth to explore. A potent and stable ferroptosis specific inhibitor is essential for in vivo study. Ferrostatin-1 (Fer-1), the first generation of ferroptosis inhibitor, was shown actively suppressing ferroptosis

• Dysregulation of the HPA axis

  2022-04-19

  

  Dysregulation of the HPA axis, resulting in alteration to both baseline and stress-induced glucocorticoid levels (e.g., cortisol and corticosterone), has been implicated in several diseases and psychopathologies, including anxiety (McEwen et al., 2015, 2016; Shin and Liberzon, 2010). For example, ba

• Enhancer of zeste homolog EZH which functions as a methyltra

  2022-04-19

  

  Enhancer of zeste homolog 2 (EZH2), which functions as a methyltransferase, is a critical subunit of polycomb repressive complex 2 (PRC2), which has been demonstrated to be involved in the development of the PF-4708671 [23]. Aberrant expression of EZH2 has been found to be associated with a variety

• We sought to deduce the role of membrane

  2022-04-19

  

  We sought to deduce the role of membrane lipid determinants on endo- and exocytosis by applying a combination of metabolic (lipid) engineering approaches and biophysical methods, e.g. classical optical imaging technologies and high-resolution time-resolved patch-clamp/capacitance measurements. The

14041 records 324/937 page Previous Next First page 上5页 321322323324325 下5页 Last page