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Fluorescein RNA Another consistent observation in our
2022-01-31
Another consistent observation in our studies was the lower plasma catecholamine concentrations in the exercised GHSR-null mice, suggesting a diminished sympathoadrenal response. A proper sympathoadrenal response is essential for increasing substrate utilization during exercise [81]. Thus, the reduc
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As many of the above
2022-01-31
As many of the above studies highlight, several decades of research on Cx43 has revealed that many of these functional roles are attributed to the C-terminal domain (CT) of this protein which cannot be explained by the formation and existence of intercellular channels. Recent findings on the existen
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To investigate the potential molecular mechanism of
2022-01-31
To investigate the potential molecular mechanism of FXR-mediated regulation of liver cancer cell proliferation, gene expression profiles were determined using Agilent arrays in SK-Hep-1-FXR and NC after treatment with the FXR agonist GW4064. The results indicate that mTOR and S6k are involved in div
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butein In stark contrast to this study Zhang and colleagues
2022-01-31
In stark contrast to this study, Zhang and colleagues demonstrated that FFA4, along with FFA1, play roles in suppressing cell proliferation and promoting apoptosis in CRC butein treated with omega-3 PUFA [53]. In this study design, in vivo CRC was induced in mice upon treatment with the genotoxic c
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Macrocycle was synthesized as described in
2022-01-31
Macrocycle was synthesized as described in , . Under SAr conditions, 2-chloronicotinonitrile was heated with -butyl 5-aminopentanoate in refluxing ethanol (). The resulting aminopyridine was treated with mesyl chloride and the nitrile was subsequently reduced to afford amine . Chloroaminopyrimidin
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br Acknowledgments We thank Prof Alexander D Johnson and
2022-01-31
Acknowledgments We thank Prof. Alexander D. Johnson and Suzanne M. Noble for kindly providing SN strains. This work was supported by Chinese National Natural Science Foundation Grants 31370105 and 31300057, and Shanghai STCSM Grant 12JC1409300. Introduction Organisms modulate gene expression
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Furthermore a direct thiol protective role of S nitrosylatio
2022-01-30
Furthermore, a direct thiol protective role of S-nitrosylation has been reported in animals [66]. Here, formation of higher order irreversible oxidative modifications, such as sulfinic and sulfonic acids were prevented by S-nitrosylation. All these observations underline the important role of ROS in
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br Introduction Atherosclerosis is a chronic inflammatory
2022-01-30
Introduction Atherosclerosis is a chronic inflammatory disease characterized by lipid and leukocyte accumulation within the arterial wall. Homocysteine (Hcy) is a thiol-containing amino Darifenacin HBr derivative derived from the metabolism of dietary methionine. Epidemiological studies have sho
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Due to the high structural similarity between
2022-01-30
Due to the high structural similarity between GlxI and FosA, it is possible that GlxI directed evolution experiments could produce FosA enzymatic activity in a GlxI enzyme. Although the current investigation was unable to detect FosA activity by mutation of a key metal liganding residue in the activ
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Studies have revealed that ferroptosis
2022-01-30
Studies have revealed that ferroptosis is non-apoptotic and peroxidation-driven form of cell death that requires abundant and accessible cellular Fe2+, and thus, the balance of Fe2+ metabolism is of great significance in regulating the process of ferroptosis (Cao and Dixon, 2016; Xie et al., 2016; Y
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br Acknowledgments We apologize to the
2022-01-30
Acknowledgments We apologize to the researchers who were not referenced due to space limitations. We thank Christine Heiner (Department of Surgery, University of Pittsburgh) for her critical reading of the manuscript. This work was supported by grants from the US National Institutes of Health (R0
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br Methods The study was a cross sectional ecological
2022-01-29
Methods The study was a cross-sectional, ecological analysis of country-reported HIV expenditures. We obtained the most recent available and validated data on annual country-reported HIV expenditures in SSA countries between 2012 and 2017 from the UNAIDS (http://aidsinfo.unaids.org/). Many countr
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br Acknowledgments br Introduction Histone deacetylases HDAC
2022-01-29
Acknowledgments Introduction Histone deacetylases (HDACs) related to tumor suppressor genes have become promising targets for the treatment of cancer [1,2]. Under the normal physiological conditions, Histone acetyltransferases (HATs) and histone deacetylases (HDACs) together regulate the acety
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Glucagon (19-29), human br Discussion The present study expl
2022-01-29
Discussion The present study explored that the effect of the MTP gene −493G/T polymorphism on the risk of hepatic steatosis in Turkish patients with chronic HCV genotype 1 infection. Some researchers revealed that the MTP gene −493G/T polymorphism was associated with hepatic steatosis in CHC infe
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CgtA is involved in stringent response and it interacts
2022-01-29
CgtA is involved in stringent response and it interacts with SpoT to maintain optimal (p)ppGpp/ppGpp quotient in bacteria. Depletion of CgtA results in increased ppGpp levels [8]. CgtA is also important for cellular development [12] and involved in synchronization of DNA replication initiation and c
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