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br Material and methods br Results br Discussion Ligase IV
2021-07-30
Material and methods Results Discussion Ligase IV is essential for the final ligation of DSBs through the NHEJ pathway. Its co-factor, XRCC4, has been shown to be important for increasing its activity and stability. Interaction between these two factors have been mapped to the linker region
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Several highly potent CysLT receptor antagonists
2021-07-30
Several highly potent CysLT1 receptor antagonists with large structural dna synthesis have been developed. Beyond antagonists with structures analogous to cysteinyl leukotrienes, other subclasses comprise: (a) hydroxyacetophenones, (b) indoles and indazoles, (c) quinolines, benzothiazoles, and thia
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br Amygdala microcircuitry and fear learning Recent work has
2021-07-30
Amygdala microcircuitry and fear learning Recent work has begun to dissect functional amygdala circuits that are responsible for the acquisition and expression of fear learning. Ciocchi et al. (2010) identified separable populations of Piroxicam within the CeAL that have opposite responses to CS
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Multiple lines of evidence now indicate that
2021-07-30
Multiple lines of evidence now indicate that mitochondrial decay is a fundamental factor that leads to alterations in energy metabolism in the aged heart (Hagen et al., 2002, Judge and Leeuwenburgh, 2007, Lesnefsky et al., 2001c). Nevertheless, the exact biochemical events that cause such an alterat
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br Study design br Results We
2021-07-29
Study design Results We enrolled 50 subjects awaiting SOT (15 kidney, 14 liver, 1 liver + small bowel, 11 lung, 9 heart) and 50 controls (Table 1) who were similar with respect to median age (subjects 49.1 yrs., controls 48.6 yrs.) gender (64% male subjects and controls), and CMV-seropositivit
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br Third trimester crossing the threshold to immunocompetenc
2021-07-29
Third trimester – crossing the threshold to immunocompetence Summary Regrettably, studies on the fetal immune system have yet to yield practical results. While it is becoming apparent that the fetal immune response plays a role in determining the outcome of congenital CMV infection, we still l
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br Genomic and non genomic signaling crosstalk As exemplifie
2021-07-29
Genomic and non-genomic signaling crosstalk As exemplified in the previous sections, it is evident that the mechanisms of action of estrogen in the various cell targets represent a combination of complex multifactorial processes. Besides the independent genomic and non-genomic pathways described
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br Acknowledgments This work was
2021-07-29
Acknowledgments This work was supported by Région Auvergne “Nouveau chercheur”. This study has been performed with the assistance of Christelle Damon-Soubeyrand for histology technical assistance using “Anipath” Platform (GReD) and Sandrine Plantade, Keredine Ouchen and Philippe Mazuel for animal
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br Significance Our understanding of the ubiquitin biology
2021-07-29
Significance Our understanding of the ubiquitin biology has been rapidly expanding. The role of the ubiquitin system in the pathogenesis of numerous disease states has increased the interest in finding new strategies to pharmacologically interfere with the enzymes responsible of the ubiquitinatio
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We found that the postnatal absence
2021-07-29
We found that the postnatal absence of norepinephrine yields differing effects depending on noradrenergic receptor type and VUF 10166 mg region. The density of α1-AR, indicated by [3H]prazosin binding was similar between Dbh+/− and Dbh−/− mice except for a significant increase in hippocampus in Dbh
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Traditionally serum triglycerides have been measured in
2021-07-29
Traditionally, serum triglycerides have been measured in the clinic in the fasted state in order to reduce variability and also to facilitate the calculation of LDL-cholesterol via the Friedewald equation, which was derived using fasted samples (Warnick and Nakajima, 2008). We have previously report
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Several evidences showed that seizures increase brain extrac
2021-07-29
Several evidences showed that seizures increase brain extracellular glutamate, which binds to N-methyl-d-aspartate (NMDA) receptor, then up-regulated cyclooxygenase-2 (COX-2) expression in brain capillaries to increase BBB P-gp expression [11,13,29,30]. A recent study demonstrated a different signal
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br Acknowledgements This work was supported
2021-07-29
Acknowledgements This work was supported by the National Institute of Neurologic Disorders and Stroke (U54 HD061222, 1K23 NS107646-01, and 1K12NS089417-01), Rocky Mountain Rett Association, International Foundation for CDKL5 Research, the Ponzio Family Chair in Neurology Research, and NHMRC Senio
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pimaricin br Acknowledgments This work was supported by Natu
2021-07-29
Acknowledgments This work was supported by Natural Science Foundation of China (No: 81501485). We are particularly grateful to Dr. Dan Yang and Dr. Yi Zhang for their assistance and facilities in helping this experiment and manuscript. Oral squamous cell carcinoma (OSCC), the most common malig
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The mammalian two hybrid results described above were
2021-07-29
The mammalian two-hybrid results described above were all obtained in 293T cells, and thus the higher RLU observed specific to the hCrm1 fusion could be consistent with human HOBt having an unknown activator that interacts with hCrm1 HEAT repeat 9A and somehow facilitates Crm1-Rev/RRE function. Alt
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