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Recent studies investigating the effects of mesenchymal stem
2021-05-21
Recent studies investigating the effects of mesenchymal stem cell (MSC) therapy in rodent models including chronic renal failure and glomerulonephritis have demonstrated that MSC therapy can result in beneficial effects [57], [58]. In cats, autologous intra-renal injections of either adipose tissue-
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br Results br Discussion br Experimental Procedures br Autho
2021-05-20
Results Discussion Experimental Procedures Author Contributions Acknowledgments Introduction Excitatory synaptic transmission within the brain is largely mediated by ionotropic glutamate receptors. At glutamatergic synapses, α-amino-3-hydroxy-5-methylisoxazole-4-proprionic MS436 (
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Introduction The inflammation process involves sequential ac
2021-05-20
Introduction The inflammation process involves sequential activation of signaling molecules, pro-inflammatory mediators, such as prostaglandins, leukotrienes, and oxygen free radicals [1]. Two cyclooxygenases Loxapine Succinate synthesis were responsible for activation of the production of prostag
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It is well known that
2021-05-20
It is well known that Doxorubicin-induced cardiotoxicity occurs via p53-mediated apoptosis (Lorusso et al., 2007). However, there are few studies elucidating the mechanism of HFS induced by PLD. We found that PLD induces keratinocyte apoptosis in a very low dose, and the damage induced by PLD cannot
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Synthetic progestogens also known as synthetic gestagens
2021-05-20
Synthetic progestogens (also known as ‘synthetic gestagens’, ‘synthetic progestins’ or simply ‘progestins’) are designed to mimic the effects of progesterone (P4) and are the active pharmaceutical ingredient in many contraceptives and hormone replacement therapies. Since most progestins are derived
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Prostaglandin E PGE is involved in several biological proces
2021-05-20
Prostaglandin E2 (PGE2) is involved in several biological processes such as renal function, inflammation, angiogenesis, and tumor growth. The various biological effects of PGE2 are mediated by the so-called E-type prostanoid receptors (EP1 to EP4). Among these, the EP4 receptor has been well studied
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br Introduction br Structure of the Ku
2021-05-20
Introduction Structure of the Ku heterodimer associated to DNA The atomic structure of the Ku heterodimer, alone and bound to a small DNA fragment, was recently determined (Walker et al., 2001) and has significantly improved our understanding of DNA recognition by DNA-PK holoenzyme (Fig. 3). B
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br Results and Discussion br Experimental Procedures br Ackn
2021-05-20
Results and Discussion Experimental Procedures Acknowledgments The ubiquitin–proteasome system (UPS) is important for biological processes such as protein degradation and protein function regulation. In general, poly-ubiquitinated proteins are degraded by proteasomes, and some proteins ac
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br Results and discussion br Conclusion In the current study
2021-05-20
Results and discussion Conclusion In the current study, a series of novel ‘open-chain’ classes of E. coli PDHc E1 inhibitors, N-acylhydrazone pyrimidine derivatives A, B, and C were designed and synthesized. As novel ThDP analogs, all A displayed moderate to powerful inhibitory activity with I
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In contrast to G and G which are
2021-05-20
In GNF 2 to G468 and G469, which are buried (Fig. 7a), residues 470–476 are equivalent to the surface loop L12 present in the crystal structure of the LigI complex (Fig. 7b) [17]. The OBD of DNA ligases adopts at least two distinct orientations during the catalytic cycle. In the adenylation step, t
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Are the hydrogens removed simultaneously or one by one KSTDs
2021-05-20
Are the hydrogens removed simultaneously or one by one? — Δ1-KSTDs can catalyze the exchange of alkali-labile tritium or deuterium atoms at the C2 NHS-12-Biotin of their substrates, even when enzyme turnover was prevented by the absence of an electron acceptor for the oxidative half-reaction [97,98
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Functional studies suggested the presence of a cysLT
2021-05-19
Functional studies suggested the presence of a cysLT1 receptor. We observed an LTD4-induced cytosolic calcium response, albeit one that was very weak by most standards. The magnitude of the average response was partially explained by the low percentage of Dimethyl Fumarate showing a very transient
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Pyrazolopyrimidines are bioisostere of purine exhibit promis
2021-05-19
Pyrazolopyrimidines are bioisostere of purine exhibit promising antitumor activity by competitively binding to the ATP active site of different kinase Tirofiban [16,17]. Several compounds of this family were found to induce apoptosis and/or reduce cell proliferation in various solid tumour and leuka
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Nevertheless of the different types of scoring systems so
2021-05-19
Nevertheless, of the different types of scoring systems so far proposed, each of these [14], [29], [30] considered some aspects that could describe the fibrotic evolution, though none provided a quantitative assessment. Calvaruso et al. [8] showed that CPA had a better histological correlation with
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Polymyxin B sulfate The COMT gene is involved
2021-05-19
The COMT gene is involved in numerous psychological and physiologic processes, including modulation of pain. Polymorphisms in this gene have also been associated with many painful conditions, including pain sensitivity in children. Bivariate analysis demonstrated that individuals with heterozygous C
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