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br Conflict of interest br
2020-08-10
Conflict of interest Acknowledgements This work was supported by Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP: 2014/00926-3). Introduction The metacestodes of Taenia solium are the causative agent of cysticercosis, which mainly resides the skeletal muscles and the central n
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To predict levels of SCF assembly Liu
2020-08-10
To predict levels of SCF assembly, Liu et al. (2018) first quantified the remaining necessary kinetic parameters and derived a model in combination with known functions and concentrations of components. The model agrees astonishingly well with many experimental observables. In terms of SCF assembly,
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The structure of the HOIP RBR
2020-08-10
The structure of the HOIP RBR–LDD module bound to UbcH5~Ub reveals insights into an activated HOIP component [47]. Contacts between the E2~Ub and the non-cognate RBR module in the crystal suggest how a structure in which the active sites of the E2 and the E3 are in close proximity might look. In thi
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br Materials and methods br Results br Discussion In our
2020-08-08
Materials and methods Results Discussion In our tissue array, we demonstrated that 14-3-3 tau mRNA and protein expression levels decreased in the preeclamptic placentas. 14-3-3 proteins are considered to be important in the functional regulation of trophoblasts and maybe associated with adv
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Finally by injecting zymosan A into
2020-08-08
Finally, by injecting zymosan A into the hindpaw the contribution of EP1 to pain sensitization was studied in a model that resembles a more complex natural inflammation (). This was particularly important as the expression of EP receptors might change during inflammation. In wild-type mice, zymosan
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TTP 22 We show that LNX makes additional
2020-08-08
We show that LNX1 makes additional contacts with Ub to impose this “closed” conformation, with N-terminal loop residues Asp36, Asp38, and Lys100 of LNX1A contacting the Lys11 of UbA (Fig. 5b). A recent report noted the formation of a similar contact between glutamate (Glu10) of TRIM25 and Lys11 of U
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It was found that D like
2020-08-07
It was found that D1-like DRs (DRD1 and DRD5) levels increased in the VTA of OA. As D1-like DRs do not express in dopaminergic neurons [44], the enhancement of the receptors may occur in VTA glutamatergic neurons. Glutamate neurons in VTA are a part of VTA micro-circuitry which can excite dopaminerg
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Our finding that the ATRX DAXX H complex promotes a
2020-08-07
Our finding that the ATRX-DAXX-H3.3 complex promotes a form of HR is likely to have important implications for our understanding of the ALT recombination process that takes place at telomeres. We were surprised to observe that ATRX promotes a form of HR, since loss of the ATRX-DAXX-H3.3 complex is n
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Industrial fermentation aims to produce valuable products fr
2020-08-07
Industrial fermentation aims to produce valuable products from cheap feedstocks by utilizing diverse microbial functions through aerobic or anaerobic fermentation [[8], [9], [10]]. During anaerobic fermentation, the reducing power is mostly directed to product synthesis rather than being oxidized, r
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br The PQQ and heme
2020-08-07
The PQQ and heme b cofactors of CcPDH are located in the 45 kDa AA12 and the 21 kDa AA8-cytochrome domains, respectively, and these domains are connected by a proline-rich linker region. The domain organization of CcPDH resembles those of some CDHs, which have a flavin-containing AA3 domain instea
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DNA ligase IV expression was also
2020-08-06
DNA ligase IV expression was also enhanced in DNR-resistant subclones (Fig. 1). KU80- and DNA ligase IV-deficient plants are reportedly sensitive to ionizing radiation [53]. The regulatory mechanism of DNA ligase IV has not been reported yet. Sp1 expression reduced by siRNA and Sp1 inhibitor suppres
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Less stringent mining of the literature using the term DDR
2020-08-06
Less stringent mining of the literature using the term ‘DDR1’ in potent web search tools such as Thomson Integrity [83] yields an impressive number of results for both scientific publications and patents (respectively 1219 and 267) in multiple indications (Fig. 4B). Unfortunately, the majority of th
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br Experimental procedures br Results
2020-08-06
Experimental procedures Results Experiment 1: SERT−/− rats show no fear-potentiated startle. With both shock intensities, genotypes differed in their response to cued and non-cued trials (trial×genotype interaction: [F2,42=4.9, pToremifene on non-cued trials [F2,42expression of fear-potenti
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Bayesian networks have become an alternative approach to sur
2020-08-06
Bayesian networks have become an alternative approach to survival analysis. They are well-structured, intuitive, while also being theoretically sound [7]. They have the ability to capture expert knowledge, handle model complexity, and offer more flexibility in model interpretation [6]. Researchers c
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In an aging condition the decreased
2020-08-05
In an aging condition, the decreased pattern of eNOS Ser1177 was observed, and its activity decreased with passage progression in the endothelial cells. Phosphorylation of eNOS includes post-translational modifications and is responsible and somehow representative of its activity. eNOS has various s
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