• In molecular genetics most synovial sarcomas demonstrate a

  2018-10-29

  

  In molecular genetics, most synovial sarcomas (90%) demonstrate a specific translocation between chromosome X and chromosome 18 (p11.2; q11.2). This includes the SYT gene on chromosome 18 and one of several homologous genes (SSX1, SSX2, and SSX4) on the X chromosome. This leads to the expression of

• br Traumatic thoracolumbar spine fractures br Traumatic frac

  2018-10-29

  

  Traumatic thoracolumbar spine fractures Traumatic fractures of the thoracolumbar spine, particularly the thoracolumbar junction (T10–L2), are the most common fractures of the spinal column. Percutaneous pedicle screw instrumentation (PPSI) has been used for treating various trauma patterns. For

• ryanodine manufacturer br Maternal obesity high fat feeding

  2018-10-29

  

  Maternal obesity/high fat feeding The prevalence of maternal obesity is increasing at an alarming rate [21], however, the consequences for the health of the offspring in later life is poorly understood compared with that of fetal undernutrition and fetal growth restriction. In various experimenta

• Analgesia is an important ancillary property

  2018-10-29

  

  Analgesia is an important ancillary property of all anti-inflammatory agents. Most of the anti-inflammatory drugs increased pain threshold in various animal models [44]. This is natural because many endogenous chemical mediators of inflammation play a part in generating pain impulses (for example, h

• br Materials and methods br Results and discussion

  2018-10-29

  

  Materials and methods Results and discussion The dose-dependent inhibition of HMG-CoA reductase activity by the extracts as presented in Fig. 1 and the IC50 values in Table 1 showed that there was no significant (P>0.05) difference in the inhibitory abilities of the two extracts. The control o

• Qiu et al illustrated the in vivo and

  2018-10-29

  

  Qiu et al. [112] illustrated the in vivo and in vitro secretin receptor of theasinensins A and B and evaluated their transport pathway across intestinal membrane. The rat study showed that a single oral administration of theasinensins demonstrated the intact absorption of theasinensins into the blo

• There are mounting evidences supporting GM foods are safe

  2018-10-29

  

  There are mounting evidences supporting GM foods are safe. In 2013, Nicolia et al. published a study which systematically reviewed a total of 1783 scientific papers on the safety of GM crops published from 2002 to October 2012. This report concluded that there is no evidence showing the use of GM cr

• Previous experiments with mouse chimaeras

  2018-10-29

  

  Previous experiments with mouse chimaeras and X-inactivation mosaics (Collinson et al., 2002, 2004; Mort et al., 2009) suggested that the numbers of active LESC clones decline with age in wild-type mice and are reduced in Pax6+/− heterozygotes. Although this would imply that LESC function is deficie

• Based on our analysis of XCI in

  2018-10-29

  

  Based on our analysis of XCI in hESCs and hiPSCs we propose a model in which pluripotent stem papain show three states of XCI: lines with no XCI, lines with full XCI, and lines with partial XCI (Fig. 4). hESCs are derived from early embryos and therefore start out with two active X chromosomes. Thu

• RA plays an instrumental role in neuronal differentiation

  2018-10-29

  

  RA plays an instrumental role in neuronal differentiation and neuronal patterning as well as motor axon generation. In addition, RA is required for the maintenance of mature adult neurons (reviewed in Ferri et al., 2007). Various concentrations of RA (from 1 to 10μM) have been used to induce ESCs in

• In our model DNA damage forces cells into

  2018-10-29

  

  In our model, DNA damage forces cells into cellular senescence, whereas ATM-dependent and p53-antagonized cytokine secretion activates BMP2/JAK-STAT signaling and stimulates the differentiation process in a progressive feed-forward manner. This senescent state is very different from the GFAP-associa

• br Materials and methods br Results br Discussion Using a

  2018-10-26

  

  Materials and methods Results Discussion Using a dual-promoter lentivirus-transduced BM-HSC transplantation model, we report here that both transgenes (i.e. murine invariant chain (Ii) and the GFP reporter) can be detected in various APC cell types from different organs (Fig. 1). Thus, this

• Results br Discussion In this

  2018-10-26

  

  Results Discussion In this study, we described the differentiation of hiPSCs into efficient functional ECs and compared them with hESC-ECs. We have found that hiPSCs, similar to hESCs, can be differentiated into ECs by the use of a sequential combination of FLK1-positive (EPC marker) and CD31-po

• In demyelinating diseases injury of myelin oligodendrocytes

  2018-10-26

  

  In demyelinating diseases, injury of myelin/oligodendrocytes results in a profound loss of myelin sheaths, axonal injury and degeneration, which eventually lead to long-lasting functional disabilities (Franklin and Ffrench-Constant, 2008; Emery, 2010). Mouse models of oligodendrocyte injury, such as

• br Results br Discussion The data presented herein substanti

  2018-10-26

  

  Results Discussion The data presented herein substantially expand the potential of developing CSC-targeted therapy based on inhibition of the SUMO pathway. We show that inhibition of sumoylation by knockdown of UBC9 and PIAS1 effectively repressed expression of MMP14 and CD44, reduced invasive

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