• The specific mutations in the EGFR gene of

  2018-10-25

  

  The specific mutations in the EGFR gene of NSCLC are correlated with clinical responsiveness to the TKI gefitinib. These mutations lead to the increase of growth factor signaling and susceptibility to the inhibitor. Such mutations in NSCLC lead to the good response to cetuximab and panitumumab that

• In this regard induced pluripotent stem

  2018-10-24

  

  In this regard, induced pluripotent stem squalene epoxidase (iPSCs) converge to a better-defined ground state of pluripotency (Hackett et al., 2013). They can be differentiated into all cell types of the organism and—while in pluripotent state—cultured virtually indefinitely without signs of replic

• We used two complementary methods MO based

  2018-10-24

  

  We used two complementary methods, MO-based knockdown and cell transplantation, to generate zebrafish containing a spectrum of PGC numbers. Our findings revealed that a threshold number of PGCs is required for the stability of ovarian fate. Furthermore, no compensatory proliferation of germ Deforoli

• In contrast to the attention

  2018-10-24

  

  In contrast to the attention devoted to GDNF, little work has focused on exploration of the role played by fibroblast growth factor 2 (FGF2), which is thought to be essential for SSC self-renewal (Kanatsu-Shinohara and Shinohara, 2013). The effects of FGF2 have been analyzed in vitro. FGF2 induces b

• A common shortcoming of iHLCs and other iPSC derived

  2018-10-24

  

  A common shortcoming of iHLCs and other iPSC-derived cloprostenol lies in the fact that they often resemble a developmentally immature state compared to the fully differentiated adult counterpart (Engle and Puppala, 2013). In the field of iHLCs, current in vitro differentiation protocols result in t

• In the controversial field of

  2018-10-24

  

  In the controversial field of pluripotent stem cell research, it is vital to argue on the basis of reliable and solid data that best reflect the actual research situation and are carefully validated. However, available data on recent research activities in this field are often based on abstract sear

• In addition to apoptosis we investigated the occurrence of D

  2018-10-24

  

  In addition to apoptosis, we investigated the occurrence of DNA lesions in response to genotoxic insults. Using LORD-Q analyses, a novel sensitive technique to quantify DNA lesions (Lehle et al., 2014), we found that, despite their elevated apoptosis sensitivity, iPSCs accumulated significantly less

• Pax is a well known neurogenic transcription factor

  2018-10-24

  

  Pax6 is a well-known neurogenic transcription factor that is essential for the development of multiple neural tissues (Gehring and Ikeo, 1999; Georgala et al., 2011; Zhang et al., 2010). Due to its important role in neuronal development, Pax6 was often included in the initial screening for essential

• To establish whether replacement of lost podocytes by

  2018-10-24

  

  To establish whether replacement of lost podocytes by RPCs could influence CKD outcome, we traced podocyte regeneration to compare mice that underwent proteinuria remission with those that developed persistent proteinuria and CKD using two different lineage-tracing strategies. By tracking podocytes

• Importantly STS and STS have been shown to have overlapping

  2018-10-24

  

  Importantly, STS1 and STS2 have been shown to have overlapping functions (Carpino et al., 2002; Carpino et al., 2004). However, although expansion of LSK, increased serial colony growth, and hyperphosphorylation of FLT3 were largely attributable to the loss of STS1, further loss of STS2 strengthened

• Several approaches exist to prevent allogeneic cell

  2018-10-24

  

  Several approaches exist to prevent allogeneic cell transplantation-related immune rejection. One is immune suppression therapy using a combination of several different types of immunosuppressants. Others are the use of major histocompatibility complex (MHC)-matched donor cells to reduce immunogenic

• The capacity to delay cell cycle progression at

  2018-10-24

  

  The capacity to delay cell-cycle progression at the G1/S transition is central to tumor suppression by RB proteins, predominantly via interaction with, and inhibition of, the E2F family of S-phase transcriptional activators. In Drosophila, the role of Rbf proteins in cell-cycle regulation is conside

• br Problem setting PS M V a presenilin model implying

  2018-10-24

  

  Problem setting PS1-M146V, a presenilin model implying the presence of a mutation in the gene encoding the presenilin protein [7]; APPKI, an amyloid model implying the presence of a mutation in the gene encoding APP [9]. Recently, our laboratory has developed one more model which, in beta lacta

• tsa hdac br If the quality of vibration suppression in the

  2018-10-24

  

  If the quality of vibration suppression in the beam proves unsatisfactory, it is necessary to return to identification experiments and additionally determine the subsequent rows of the eigenmode matrices. Next, it is necessary to recalculate the modal matrices according to formula (7) and use them

• To examine whether the associations were

  2018-10-24

  

  To examine whether the associations were consistent with a particular causal direction, we next explored associations between health and Cy3.5 hydrazide capacity in the opposite direction (Table 5). Here we found no evidence of an association between health and any community capacity measure aside f

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