• Repurposing use of approved drugs for new indications or

  2019-06-18

  

  Repurposing (use of approved drugs for new indications) or repositioning (use of drugs whose development was not continued for new indications) of existing drugs has been put forward as a method to overcome some of these issues. Indeed, drug repositioning and repurposing could lead to higher rates o

• Las colaboraciones de Woinoff conforman el ltimo v rtice de

  2019-06-18

  

  Las colaboraciones de “Woinoff ” conforman el último vértice de la constelación intelectual que, why nuestro juicio, pudo haber ayudado en el cambio intelectual de Bilbao. En ellas, el pretendido “atraso” se vuelve reserva moral desde la cual la democracia radical europea puede pensar de manera inéd

• Assim pensamos que os discursos analisados neste artigo

  2019-06-18

  

  Assim, pensamos que os discursos, analisados neste artigo, construídos pelos intelectuais colaboradores de Araucaria de Chile e difundidos pela revista, ao ressaltarem duas vitoriosas revoluções armadas latino-americanas, exatamente no período de vigência da prpm, dialogaram, de alguma maneira, com

• We are delighted to introduce you to the

  2019-06-18

  

  We are delighted to introduce you to the inaugural issue of , a journal that will join and to provide a third pillar in an open-access programme covering the interplay between health and the determinants of health in our living and physical world. What is planetary health? And what kind of science

• All these receptors tightly control tissue

  2019-06-18

  

  All these receptors tightly control tissue homeostasis, and any dysregulation of these ligand–receptor systems (mutations, overexpression, etc.) disturbs cell communication and leads to pathological situations. Bone formation and bone remodelling are then controlled by a large panel of cytokines and

• Performing an ajmaline test in children is problematic

  2019-06-18

  

  Performing an ajmaline test in children is problematic for 2 reasons. First, the test is apparently less sensitive in children than in adults. In fact, in 1 study, a repeat ajmaline challenge performed after puberty unmasked BrS in 23% of relatives with a previously negative drug test performed duri

• Pero en los a os noventa como refere Brito

  2019-06-18

  

  Pero en los años noventa, como refere Brito, al inventariarse los resultados de la estrategia de desarrollo y de las reformas adelantadas en la década anterior, es decir ante una revisión “crítica” del “Consenso de Washington”, fue evidente que los costos en términos de inequidad y dualización socia

• Qu decir sobre los Estudios

  2019-06-18

  

  Qué decir sobre los “Estudios Culturales Latinoamericanos ()”? ¿Es pertinente pensar que los constituyen una corriente académica de análisis e interpretación y conforman una escuela? ¿Qué especificidades tendrían? ¿Qué debilidades? ¿Qué hace que un estudioso del pensamiento, la cultura, la literatu

• Feeding stimulates gallbladder contraction emptying its cont

  2019-06-17

  

  Feeding stimulates gallbladder contraction, emptying its contents into the upper part of the small intestine, where CBAs activate pancreatic lipase to release monoglycerides and free fatty acids from triglycerides. Mixed micelles with monoglycerides, fatty acids, cholesterol, and fat-soluble vitamin

• While it has been reported that

  2019-06-17

  

  While it has been reported that the combination therapy of As2O3 and ATRA is highly effective not only as the front-line treatment [6], but also in relapsed and treatment-refractory APL patients [7], showing fewer adverse events than the combination of ATRA and chemotherapeutic drugs, the efficacy a

• br Methods br Results br Discussion

  2019-06-17

  

  Methods Results Discussion A. baumannii remains one of the most common nosocomial pathogens and frequent causes of outbreaks in burn wound infections. Unfortunately, most of the isolates are resistant to antimicrobial agents. β-Lactamases are microbial enzymes that hydrolytically inactivate

• br Discussion br Conflict of interest br Introduction

  2019-06-17

  

  Discussion Conflict of interest Introduction Device implantations may be challenging in patients with venous abnormalities. The most common congenital variation, frequently associated with other congenital abnormalities, is a persistent left superior vena cava (PLSVC), and successful atrial

• br Results As shown in Table the

  2019-06-17

  

  Results As shown in Table 1, the amplitude, and the onset or the end of LA potentials were successfully determined via visual inspection. Among 19 patients with AP, LA potentials were detected in 7 (37%), all in an LA → CSM activation sequence (Fig. 2). In contrast, among 21 patients with CCW AFL

• Estas ideas permanecieron vigentes durante mucho tiempo ante

  2019-06-17

  

  Estas ideas permanecieron vigentes durante mucho tiempo antes de la revolución científica desatada por el racionalismo. Un ejemplo es cómo las nociones neumáticas —derivadas de la idea de que el mundo fue creado por un soplo divino— todavía son palpables en el Primero sueño de sor Juana cuando inici

• The development in high income

  2019-06-15

  

  The development in high-income countries shows the possibilities for progress in twin health and survival: Danish twins born between 1870 and 1900 had higher early-life mortality rates than twins born in the late 20th century and contemporary sub-Saharan twins, with about 40% under-6 mortality (doub

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