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Phosphorylation of the p Rel A dimer the
2022-08-11
Phosphorylation of the p50-Rel A dimer, the most common form of NF-κB, leads to ubiquitination of IκB proteins (Fig. 2). Poly-ubiquitination of IκB proteins identifies them for rapid degradation by 26S proteasomes, thereby allowing NF-κB dimers to undergo nuclear translocation and activate the trans
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Not only has the cortical actin
2022-08-11
Not only has the cortical valeriana te mg network been found to influence plasma membrane properties but also to interact with exo- and endocytic vesicles (Gormal et al., 2015, Tomatis et al., 2013). The interplay between actin and membranes is integrally regulated by the phosphoinositide compositi
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br STAR Methods br Acknowledgments We thank the Shanghai Syn
2022-08-11
STAR★Methods Acknowledgments We thank the Shanghai Synchrotron Radiation Facility (SSRF) BL18U for help with X-ray data collection. We thank Dr. Thomas F.J. Martin for providing the pcDNA3.1-CAPS-1 plasmid and Dr. Xiaofei Yang for providing the pFHUUIG_shortU6 (l309) plasmid. We thank Dr. Shun
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On the other hand G a
2022-08-11
On the other hand, G9a/GLP could also alter neuronal function without directly altering the transcription level of particular plasticity-related protein: the consolidation of early-LTP to late-LTP, as well as the reversal of mGluR-LTD by G9a/GLP inhibition required PKMζ translation and its downstrea
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MHC class II antigen (45-57) [Homo sapiens] synthesis Parkin
2022-08-11
Parkinson's disease is another neurodegenerative disorder affecting H3Rs. The most common clinical symptoms of this disease are rigidity, bradykinesia, rest tremor, loss of postural reflexes, and gain impairment owing to progressive degeneration of the dopaminergic neurons in the nigro-striatal neur
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Although we showed that RBL
2022-08-11
Although we showed that RBL-2H3 Sc98 JP 1302 dihydrochloride took up histamine from the microenvironment, it was unclear which transporter mediated its passage across the plasma membrane. Other biogenic amines have selective transporters that belong to the neurotransmitter sodium symporter family,
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Yap and Taz may regulate epicardial cell proliferation
2022-08-11
Yap and Taz may regulate epicardial cell proliferation, EMT, and fate determination via multiple mechanisms. In this study, we provide evidence that Yap/Taz function in part by directly modulating Tbx18 and Wt1 expression. Members of the T-box family of transcription factors regulate a variety of de
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Substrate affinity and specificity can
2022-08-11
Substrate affinity and specificity can be enhanced by docking interactions, in which regions distal to the site of nigericin bind to grooves, pockets, or surfaces outside of the kinase catalytic cleft 1, 2, 5, 6. Like catalytic site interactions, docking interactions can involve recognition of short
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Conflict of Interest The authors have no
2022-08-11
Conflict of Interest: The authors have no conflicts of interest to declare. Acknowledgments Understanding Pulmonary Remodeling The effects of serotonin (5-hydroxytryptamine, 5-HT) class 2 receptors (5-HT2) on airway function and remodeling in respiratory disorders are unclear. Using murine pr
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br Amino acid usage in cancer br Perspective High glucose
2022-08-11
Amino saha histone usage in cancer Perspective High glucose consumption is a common feature of several types of tumor cells. Therefore, so far, in vivo positron emission tomography (PET) imaging with the glucose analog 18F-fluorodeoxyglucose (18F-FDG) has been used to detect various tumors. Ho
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br FFA GPR was deorphanised as the
2022-08-11
FFA4 GPR120 was deorphanised as the second receptor for long-chain fatty acids in 2005 [5]. Initial focus highlighted expression in the lower gut, the capacity of unsaturated fatty acids to promote release of the incretin glucagon-like peptide-1 (GLP-1) from the enteroendocrine cell line STC-1, a
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In the present study we
2022-08-10
In the present study we set out to discover new non-steroidal SEGRA and to analyse their mechanism of function. Towards this goal we initiated a virtual screening (VS) approach, utilizing structure-based pharmacophore modeling, in silico docking and molecular dynamics (MD) simulations. Our pharmacop
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The relationship between estrogen and the Hedgehog pathway a
2022-08-10
The relationship between estrogen and the Hedgehog pathway as well as the associated mechanism have already been investigated in many tissues, especially in breast cancer (Chang et al., 2012, Katayama et al., 2006, Ramaswamy et al., 2012). Hitherto, even though we have proved that HH-Gli pathway pro
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br Experimental br Results and
2022-08-10
Experimental Results and discussion Conclusion In conclusion, four bisnaphthalimides have been investigated for their potential G-quadruplex binding. The compounds 3a, 3b and 5b display high affinity for telomeric and oncogenic G-quadruplexes. On the other hand, 5a only show high affinity f
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All of the abovementioned effects of PUFAs
2022-08-10
All of the abovementioned effects of PUFAs signal their involvement in a cellular phenotype switching phenomenon, which is increasingly recognized as a potential target for future pharmacotherapies of atherosclerosis, especially for individuals who do not respond to the classical lipid-lowering stra